TRP channels and G protein-coupled receptors (GPCRs) play critical roles in sensory reception.However, the identities of the chaperones that assist GPCRs in translocating from the endoplasmic reticulum (ER) are limited, and TRP ER chaperones are virtually unknown.The one exception Chromium for TRPs is Drosophila XPORT.Here, we show that the xport l
Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high
BackgroundHepatocellular carcinoma Chapstick is a pathological type of liver cancer and accounts for the majority of primary liver cancers.We conducted a meta-analysis to evaluate the efficacy and safety of immune checkpoint inhibitors in combination with antiangiogenic drugs in the treatment of hepatocellular carcinoma.MethodsWe searched scientifi
Uninhabited islands have an important role in supporting the socio-economic and ecological development in Zhoushan City.To promote the refined management and sustainability for uninhabited islands, this paper analyzed the underlying problems Probes of the utilization and conservation in Zhoushan City, and proposed the principles of categorized prot